diff --git a/changelog.d/3207.bugfix.rst b/changelog.d/3207.bugfix.rst
new file mode 100644
index 000000000..951e90adc
--- /dev/null
+++ b/changelog.d/3207.bugfix.rst
@@ -0,0 +1 @@
+Red will now prevent users from locking themselves out with localblacklist.
diff --git a/changelog.d/3221.bugfix.1.rst b/changelog.d/3221.bugfix.1.rst
new file mode 100644
index 000000000..73bad6df3
--- /dev/null
+++ b/changelog.d/3221.bugfix.1.rst
@@ -0,0 +1 @@
+Red will now prevent users from locking guild owner out with localblacklist (unless the command caller is bot owner).
diff --git a/changelog.d/3221.bugfix.2.rst b/changelog.d/3221.bugfix.2.rst
new file mode 100644
index 000000000..9f42f6550
--- /dev/null
+++ b/changelog.d/3221.bugfix.2.rst
@@ -0,0 +1 @@
+Guild owners are no longer affected by local whitelist and blacklist.
diff --git a/redbot/core/bot.py b/redbot/core/bot.py
index 18e57055d..858273a94 100644
--- a/redbot/core/bot.py
+++ b/redbot/core/bot.py
@@ -223,6 +223,11 @@ class RedBase(commands.GroupMixin, commands.bot.BotBase, RPCMixin):  # pylint: d
         ------
         TypeError
             Did not provide ``who`` or ``who_id``
+            
+        Returns
+        -------
+        bool
+            `True` if user is allowed to run things, `False` otherwise
         """
         # Contributor Note:
         # All config calls are delayed until needed in this section
@@ -254,6 +259,9 @@ class RedBase(commands.GroupMixin, commands.bot.BotBase, RPCMixin):  # pylint: d
                 return False
 
         if guild:
+            if guild.owner_id == who.id:
+                return True
+
             # The delayed expansion of ids to check saves time in the DM case.
             # Converting to a set reduces the total lookup time in section
             if mocked:
diff --git a/redbot/core/core_commands.py b/redbot/core/core_commands.py
index 2fe864c28..c634db6ec 100644
--- a/redbot/core/core_commands.py
+++ b/redbot/core/core_commands.py
@@ -1915,9 +1915,16 @@ class Core(commands.Cog, CoreLogic):
             user_or_role = discord.Object(id=user_or_role)
             user = True
 
-        if user and await ctx.bot.is_owner(user_or_role):
-            await ctx.send(_("You cannot blacklist an owner!"))
-            return
+        if user:
+            if user_or_role.id == ctx.author.id:
+                await ctx.send(_("You cannot blacklist yourself!"))
+                return
+            if user_or_role.id == ctx.guild.owner_id and not await ctx.bot.is_owner(ctx.author):
+                await ctx.send(_("You cannot blacklist the guild owner!"))
+                return
+            if await ctx.bot.is_owner(user_or_role):
+                await ctx.send(_("You cannot blacklist a bot owner!"))
+                return
 
         async with ctx.bot._config.guild(ctx.guild).blacklist() as curr_list:
             if user_or_role.id not in curr_list: