diff --git a/redbot/core/bot.py b/redbot/core/bot.py
index 9f1ab82bd..3355d134e 100644
--- a/redbot/core/bot.py
+++ b/redbot/core/bot.py
@@ -454,6 +454,28 @@ class RedBase(
         """
         return await self.get_prefix(NotMessage(guild))
 
+    async def set_prefixes(self, prefixes: List[str], guild: Optional[discord.Guild] = None):
+        """
+        Set global/server prefixes.
+
+        If ``guild`` is not provided (or None is passed), this will set the global prefixes.
+
+        Parameters
+        ----------
+        prefixes : List[str]
+            The prefixes you want to set. Passing empty list will reset prefixes for the ``guild``
+        guild : Optional[discord.Guild]
+            The guild you want to set the prefixes for. Omit (or pass None) to set the global prefixes
+
+        Raises
+        ------
+        TypeError
+            If ``prefixes`` is not a list of strings
+        ValueError
+            If empty list is passed to ``prefixes`` when setting global prefixes
+        """
+        await self._prefix_cache.set_prefixes(guild=guild, prefixes=prefixes)
+
     async def get_embed_color(self, location: discord.abc.Messageable) -> discord.Color:
         """
         Get the embed color for a location. This takes into account all related settings.
diff --git a/redbot/core/core_commands.py b/redbot/core/core_commands.py
index 28e389934..fb48ea48a 100644
--- a/redbot/core/core_commands.py
+++ b/redbot/core/core_commands.py
@@ -261,7 +261,7 @@ class CoreLogic:
             The current (or new) list of prefixes.
         """
         if prefixes:
-            await self.bot._prefix_cache.set_prefixes(guild=None, prefixes=prefixes)
+            await self.bot.set_prefixes(guild=None, prefixes=prefixes)
             return prefixes
         return await self.bot._prefix_cache.get_prefixes(guild=None)
 
@@ -1284,7 +1284,7 @@ class Core(commands.Cog, CoreLogic):
         if not prefixes:
             await ctx.send_help()
             return
-        await self._prefixes(prefixes)
+        await ctx.bot.set_prefixes(guild=None, prefixes=prefixes)
         await ctx.send(_("Prefix set."))
 
     @_set.command(aliases=["serverprefixes"])
@@ -1293,11 +1293,11 @@ class Core(commands.Cog, CoreLogic):
     async def serverprefix(self, ctx: commands.Context, *prefixes: str):
         """Sets [botname]'s server prefix(es)"""
         if not prefixes:
-            await ctx.bot._prefix_cache.set_prefixes(guild=ctx.guild, prefixes=[])
+            await ctx.bot.set_prefixes(guild=ctx.guild, prefixes=[])
             await ctx.send(_("Guild prefixes have been reset."))
             return
         prefixes = sorted(prefixes, reverse=True)
-        await ctx.bot._prefix_cache.set_prefixes(guild=ctx.guild, prefixes=prefixes)
+        await ctx.bot.set_prefixes(guild=ctx.guild, prefixes=prefixes)
         await ctx.send(_("Prefix set."))
 
     @_set.command()